Development of Flexible Software for Studying Peripheral Nerve Regeneration
ثبت نشده
چکیده
176 INTRODUCTION A medical diagnosis process pretty much depends on the quality of data collected from a patient and of the area under appreciation. Concerning data collection, this is required in a sufficient number containing the most relevant topics for the identification of the diagnosis and the subsequent therapeutic planning. From the 1980’s on, ischiatic nerves of different animal species have been used in studies and researches on peripheral nerve regeneration. Nervous root injuries, followed by several treatment approaches and submitted to different technique of function evaluation of the limb, have been the focus of researches particularly addressing ischiatic nerve regeneration, and peripheral nerves in general. Gait analysis conducted on the course of evaluation studies provides the researcher with a unique opportunity to assess specific aspects of nervous recovery in a non-hostile model. The accuracy of the functional index performed in nervous injuries or regenerative studies can be confirmed with the use of groups constituted of subjects (rats). Rats’ peripheral nerves are similar to human tissues. The first analysis is made with the animal in its usual state, or, as commonly named, control state. Then, the group of rats is submitted to injuries and assessed, according to the method, for the time factor. This allows the investigator to follow-up an injured nerve regeneration progress, and also helping him/ her to determine an optimal evaluation of the electrical and histological regeneration. This is called experimental state. The scope of this study was data handling by functional quanti-
منابع مشابه
The role of the desert hedgehog signaling pathway during degeneration and regeneration of peripheral nerves
The desert hedgehog (Dhh) signaling pathway is involved in the development of peripheral nerves (PNs). Dhh-null mice show abnormal neuronal development and perineurial barrier function. As it was previously shown that dhh is mainly expressed in developmental nerves and Sonic hedgehog protein (dhh homologous) has therapeutic effects in neuronal survival, we attempted to investigate the possible ...
متن کاملThe role of the desert hedgehog signaling pathway during degeneration and regeneration of peripheral nerves
The desert hedgehog (Dhh) signaling pathway is involved in the development of peripheral nerves (PNs). Dhh-null mice show abnormal neuronal development and perineurial barrier function. As it was previously shown that dhh is mainly expressed in developmental nerves and Sonic hedgehog protein (dhh homologous) has therapeutic effects in neuronal survival, we attempted to investigate the possible ...
متن کاملNanotechnology for peripheral nerve regeneration
Peripheral nerve injuries (PNI) can lead to lifetime loss of function and disfigurement. Different methods such as conventional allograft procedures and using of biological tubes have problems for damaged peripheral nerves reconstruction. Designed scaffolds with natural and synthetic materials are now widely used in the reconstruction of damaged tissues. Utilization of absorbable and non-absorb...
متن کاملEffect of Local Administration of Laminin and Fibronectin with Chitosan Conduit on Peripheral Nerve Regeneration: A Rat Sciatic Nerve Transection Model
Objective-Effect of local administration of laminin and fibronectin on nerve regeneration was assessed. Design- Experimental study. Animal- Sixty male Wistar rats. Procedures- The animals were divided into four experimental groups (n=15), randomly: In transected group left sciatic nerve was transected and stumps were fixed in adjacent muscle. In treatment group (CHIT/LF) the defect was bridg...
متن کاملنقش ماتریکس خارج سلولی در فرآیند ترمیم اعصاب محیطی
In severe injuries that led to the destruction of peripheral nerve, repair cannot be spontaneously carried out and medical intervention is required for successful regeneration of damaged nerve. In these cases, the common treatment method is use of nerve autografts, whereas this method has many limitations, nerve regeneration researchers seek to provide alternative methods. So far, one of the im...
متن کامل